15-year-old girl wit connexin-26 mutation

    A 15-year-old girl with congenital perceptive deafness, plantar keratodermia and numerous acneiform, cystic, pus-secreting nodules. A history of recidivant erythematous, gyrate changes (not evaluated by biopsy). This is a 1.5 cm nodule from the forehead with a small central  opening.

    Two prior biopsies in the archive - buccal erosions - nonspecific findings, vulvar erythematous papule - acanthotic, psoriasiform epidermis overlying abundant granulation tissue.

    A connexin-26 (GJB-2) mutation - F142L type has been confirmed.