Dr. Lyle is currently an Associate Professor of Cancer Biology and Pathology, UMass Medical School and the Director of the UMass Cancer Center Tissue Bank. Dr. Lyle is a graduate of The Pritzker School of Medicine/University of Chicago where he completed his M.D. and Ph.D. in Biochemistry and Molecular Biology. He also graduated with honors from the University of Chicago in the combined B.A. / M.S. program in Biochemistry. Prior to his training in Boston, he was a resident and surgical pathology fellow at the Hospital of the University of Pennsylvania, where he received the prestigious HT Enterline Fellowship Award. While at the University of Pennsylvania, he also completed a research post-doctoral fellowship in the lab of George Cotsarelis, M.D. in the Department of Dermatology. During this time Dr. Lyle made the breakthrough discovery of the location and characteristics of adult epithelial stem cells in human skin that launched his research career.
After finishing his clinical fellowship in the Harvard Combined Dermatopathology Program, he joined the staff at Beth Israel Deaconess Medical Center as an Assistant Professor of Harvard Medical School. In 2005 he moved to the University of Massachusetts Medical to expand his research laboratory and build the UMass Cancer Center Tissue Bank. He has an active research laboratory concentrating on adult stem cell biology, cancer stem cells and skin biology. He has received multiple awards, grants and fellowships from The National Institutes of Health, William Keck Foundation, The Ellison Foundation, Society of Investigative Dermatology, Dermatology Foundation, Burroughs Wellcome Trust, and The March of Dimes. He is a member of The American Association for the Advancement of Science, The Society of Investigative Dermatology and is a Fellow of the College of American Pathologists. He is an author on over 40 published papers.
As a practicing dermatopathologist, he has a special long-standing interest and expertise in hair disorders and adnexal tumors. He is a clinical pathology consultant for several Boston area institutions, as well as DermatopathologyConsultations.com and Dermpedia.