Acute generalized exanthematous pustulosis

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Acute-onset, generalized scarlitiniform eruption with sterile pustules, accompanied by fever
    • Self-limited course of several days to a couple of weeks
    • The etiology is a reaction to drugs, most commonly:
      • Calcium channel blockers
      • NSAIDs
      • Anticonvulsants
      • β-lactams
      • Macrolides
      • Antifungals
      • Antiarrhythmics
      • Mercury

    Histologic Features:

    • Spongiform pustulation of the epidermis, often most prominent in the hair follicles
    • Leukocytoclastic vasculitis may occasionally be seen.
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    Cases associated with this book:

  • Acute generalized exanthematous pustulosis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection