Clinical Features:

• Acute-onset, generalized scarlitiniform eruption with sterile pustules, accompanied by fever
• Self-limited course of several days to a couple of weeks
• The etiology is a reaction to drugs, most commonly:
  • Calcium channel blockers
  • NSAIDs
  • Anticonvulsants
  • β-lactams
  • Macrolides
  • Antifungals
  • Antiarrhythmics
  • Mercury

Histologic Features:

• Spongiform pustulation of the epidermis, often most prominent in the hair follicles
• Leukocytoclastic vasculitis may occasionally be seen.

Cases associated with this book:

Acute generalized exanthematous pustulosis
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection