Also known as Churg-Strauss syndrome
- Vasculitic disorder most often affecting young adults
- Cutaneous manifestations include hemorrhagic lesions (petechiae or ecchymoses) and subcutaneous nodules.
- In addition to vasculitis, patients present with asthma, fever and peripheral eosinophilia.
- p-ANCA is usually positive.
- Classic triad:
- Leukocytoclastic vasculitis
- Tissue eosinophilia
- Churg-Strauss granulomas (granulomas with epithelioid histiocytes palisading around degenerated collagen with numerous eosinophils): no longer felt to be specific
- Thrombi and extravasated red blood cells may be seen.