Also known as Churg-Strauss syndrome

Clinical Features:

• Vasculitic disorder most often affecting young adults
• Cutaneous manifestations include hemorrhagic lesions (petechiae or ecchymoses) and subcutaneous nodules.
• In addition to vasculitis, patients present with asthma, fever and peripheral eosinophilia.
• p-ANCA is usually positive.

Histologic Features:

• Classic triad:
  • Leukocytoclastic vasculitis
  • Tissue eosinophilia
  • Churg-Strauss granulomas (granulomas with epithelioid histiocytes palisading around degenerated collagen with numerous eosinophils): no longer felt to be specific
• Thrombi and extravasated red blood cells may be seen.

Cases associated with this book:

Allergic granulomatosis
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection