Angioleiomyoma

    Clinical Features:

    • Common benign tumor arising from vascular smooth muscle
    • Most common on the limbs of adults
    • Female predominance
    • May be painful

    Histologic Features:

    • Round, encapsulated mass in the deep dermis or subcutaneous fat
    • Comprised of fascicles of monotonous smooth muscle cells with numerous interspersed small blood vessels with walls of varying thickness
    • Occasional cells with enlarged, hyperchromatic nuclei may be seen: not indicative of malignancy, but probably a degenerative change.
    • Common changes include: hyaline, myxoid and dystrophic calcification.
    • If foci of mature adipose tissue are present, may be termed angiomyolipoma or angiolipoleiomyoma.
    • May rarely show epithelioid cell change or palisading mimicking Verocay bodies.
    • Postitive for smooth muscle markers: SMA, calponin, desmin, h-caldesmon

    Cases associated with this book:

  • Angioleiomyoma
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection