Clinical Features:

• Common benign tumor arising from vascular smooth muscle
• Most common on the limbs of adults
• Female predominance
• May be painful

Histologic Features:

• Round, encapsulated mass in the deep dermis or subcutaneous fat
• Comprised of fascicles of monotonous smooth muscle cells with numerous interspersed small blood vessels with walls of varying thickness
• Occasional cells with enlarged, hyperchromatic nuclei may be seen: not indicative of malignancy, but probably a degenerative change.
• Common changes include: hyaline, myxoid and dystrophic calcification.
• If foci of mature adipose tissue are present, may be termed angiomyolipoma or angiolipoleiomyoma.
• May rarely show epithelioid cell change or palisading mimicking Verocay bodies.
• Postitive for smooth muscle markers: SMA, calponin, desmin, h-caldesmon

Cases associated with this book:

Angioleiomyoma
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection