Apocrine adenoma

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Also known as: tubular apocrine adenoma, tubulopapillary hidradenoma, papillary tubular adenoma

    Clinical Features:

    • Rare benign tumor with a predilection for the scalp, cheek, axilla and breast
    • Most common in adults, with a female predominance
    • Sometimes associated with an organoid nevus or syringocystadenoma papilliferum
    • Presents as a slowly growing, well-circumscribed dermal or subcutaneous nodule

    Histologic Features:

    • Well-circumscribed dermal or occasionally subcutaneous nodule which may communicate with the epidermis
    • Composed of variably-sized tubules lined by two or more layers of apocrine-type cells: cuboidal to columnar with abundant eosinophilic cytoplasm and uniform round to oval nuclei
    • Some of the cells show decapitation secretion and an outer myoepithelial layer is focally present.
    • Many cases show cyst formation with papillae or pseudopapillae protruding into the lumen.
    • Dense fibrous stroma which contains few inflammatory cells, in contrast to syringocystadenoma papilliferum
    • The luminal surface is strongly positive for EMA and CEA.

    Cases associated with this book:

  • Apocrine adenoma
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations