Sean Klepper M.D.
Stephen Lyle, M.D., ...
- Defined as infections caused by Mycobacterium species other than M. tuberculosis and M. leprae.
- The most common organisms causing cutaneous infection are M. marinum (swimming pool granuloma), M. ulcerans (Buruli ulcer; found in Central Africa), M. avium-intracellulare (MAI; most commonly seen in patients with AIDS), M. fortuitum and M. chelonei.
- The lesions may present as abscesses, ulcers, nodules, verrucous plaques or sinus tracts, and may be solitary or multiple.
- Lesions may spread in a fashion that resembles that of sprotrichosis.
- Suppurative granulomas with or without caseation
- The overlying epidermis may be hyperplastic or ulcerated.
- Fibrosis and granulation tissue are often present, and may be florid.
- Acid-fast stains may show the organisms. The highest-yield location to them out is within microabscesses or vacuoles.
- More sensitive methods for identifying the acid-fast bacilli are fluorescent antibodies and PCR.