Clinical Features:

• In addition to the axilla, may be seen in other intertriginous sites and occasionally elsewhere
• Unknown etiology.  There is a defect in the processing of profilaggrin to filaggrin, resulting in a failure to degrade keratohyaline granules.
• Controversial association with with the use of deodorant
• Red to hyperpigmented patches that may clinically resemble acanthosis nigricans

Histologic Features:

• Thick parakeratotic stratum corneum which retains the keratohyaline granules
• The underlying epidermis may be normal, mildly atrophic or show psoriasiform hyperplasia.

Cases associated with this book:

Axillary granular keratosis
Author: Artur Zembowicz M.D. Ph.D.

Conference: Dr. Z's Consultations

Axillary granular parakeratosis
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection