Axillary granular parakeratosis

    Clinical Features:

    • In addition to the axilla, may be seen in other intertriginous sites and occasionally elsewhere
    • Unknown etiology.  There is a defect in the processing of profilaggrin to filaggrin, resulting in a failure to degrade keratohyaline granules.
    • Controversial association with with the use of deodorant
    • Red to hyperpigmented patches that may clinically resemble acanthosis nigricans

    Histologic Features:

    • Thick parakeratotic stratum corneum which retains the keratohyaline granules
    • The underlying epidermis may be normal, mildly atrophic or show psoriasiform hyperplasia.

    Cases associated with this book:

  • Axillary granular keratosis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Axillary granular parakeratosis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection