Sean Klepper M.D.
Stephen Lyle, M.D., ...
- Leukocytoclastic vasculitis can sometimes present with features resembling those of a primary blistering disorder.
- One sees tense blisters on an erythematous base, most commonly on the lower extremities.
- More typical lesions of leukocytoclastic vasculitis are usually also present (pruritic, ulcerating lesions).
- The typical features of leukocytoclastic vasculitis are present:
- Perivascular lymphocytic infiltrate with transmural vasculitis and nuclear debris
- Intravascular fibrin deposition
- Endothelial cell swelling and destruction
- Extravasated erythrocytes
- In addition, in bullous forms of the disease, one sees:
- Marked papillary dermal edema with the resultant formation of a subepidermal blister
- Sometimes epidermal necrosis, if ischemia has taken place secondary to vascular occlusion