Bullous acute vasculitis

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:

    • Leukocytoclastic vasculitis can sometimes present with features resembling those of a primary blistering disorder.
    • One sees tense blisters on an erythematous base, most commonly on the lower extremities.
    • More typical lesions of leukocytoclastic vasculitis are usually also present (pruritic, ulcerating lesions).

    Histologic Features:

    • The typical features of leukocytoclastic vasculitis are present:
      • Perivascular lymphocytic infiltrate with transmural vasculitis and nuclear debris
      • Intravascular fibrin deposition
      • Endothelial cell swelling and destruction
      • Extravasated erythrocytes
    • In addition, in bullous forms of the disease, one sees:
      • Marked papillary dermal edema with the resultant formation of a subepidermal blister
      • Sometimes epidermal necrosis, if ischemia has taken place secondary to vascular occlusion

    Cases associated with this book:

  • Bullous acute vasculitis
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Dermpedia Teaching Collection