Clinical Features:

• Autoimmune disease usually affecting elderly patients
• Tense bullae on an erythematous base, often beginning on the extremities and spreading to become generalized
• Associated with antibodies to hemidesmosome antigens

Histologic Features:

• Subepidermal blisters containing eosinophils and other inflammatory cells
• Sometimes eosinophilic spongiosis, especially in early lesions
• Superficial dermal edema and inflammation comprised of lymphocytes and eosinophils
• Immunofluorescence shows linear IgG and C3 at the dermal-epidermal junction, localizing to the roof of the blister with salt-split skin.

Cases associated with this book:

Bullous pemphigoid
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection