Sean Klepper M.D.
Artur Zembowicz M.D....
- Autoimmune disease usually affecting elderly patients
- Tense bullae on an erythematous base, often beginning on the extremities and spreading to become generalized
- Associated with antibodies to hemidesmosome antigens
- Subepidermal blisters containing eosinophils and other inflammatory cells
- Sometimes eosinophilic spongiosis, especially in early lesions
- Superficial dermal edema and inflammation comprised of lymphocytes and eosinophils
- Immunofluorescence shows linear IgG and C3 at the dermal-epidermal junction, localizing to the roof of the blister with salt-split skin.