Bullous pemphigoid

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:


    • Autoimmune disease usually affecting elderly patients
    • Tense bullae on an erythematous base, often beginning on the extremities and spreading to become generalized
    • Associated with antibodies to hemidesmosome antigens

    Histologic Features:


    • Subepidermal blisters containing eosinophils and other inflammatory cells
    • Sometimes eosinophilic spongiosis, especially in early lesions
    • Superficial dermal edema and inflammation comprised of lymphocytes and eosinophils
    • Immunofluorescence shows linear IgG and C3 at the dermal-epidermal junction, localizing to the roof of the blister with salt-split skin.
    External Links:

    Cases associated with this book:

  • Bullous pemphigoid
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection