Cholesterol embolism

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Most commonly seen in elderly patients with significant atherosclerosis
    • Frequently follows a medical procedure such as arterial catheterization, or may result from spontaneous detachment of atheromatous plaques.
    • The lower extremities are most often affected.
    • The clinical findings are variable, and can include livedo reticularis, frank gangrene or indurated nodules.

    Histologic Findings:

    • Intravascular cholesterol clefts: needle-shaped spaces representing dissolved cholesterol crystals
    • Foreign body giant cell reaction and intimal fibrosis may be seen.
    • Sometimes only fibrin thrombi are present.

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    Cases associated with this book:

  • Cholesterol embolus
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection