Chronic urticaria

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Defined as urticaria that persist for longer than 6 weeks
    • Most common in middle-aged individuals
    • Caused in some cases by IgG autoantibodies which cross-link IgE receptors on basophils and mast cells, causing their degranulation
    • Some cases are associated with allergies, especially to foods or aspirin.
    • Other cases are secondary to cholinergic urticaria, caused by an increase in body temperature following exercise, overheating or stress.

    Histologic Features (similar to what is seen in acute urticaria):

    • Dermal edema
    • Vascular dilatation and endothelial swelling
    • Scant perivascular infiltrate of lymphocytes, eosinophils and neutrophils
    • Interstitial neutrophils and mast cells
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    Cases associated with this book:

  • Chronic urticaria
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dermpedia Teaching Collection