Also known as: venereal warts
- The most common sexually transmitted disease in the United States
- Most commonly caused by HPV types 6, 8, 16 and 18
- Common sites are the external genitalia, perianal and anal areas and cervix.
- The clinical appearance varies; cutaneous lesions are commonly soft sessile tumors which may be smooth or have a cauliflower-like surface.
- Polypoid lesion
- Prominent acanthosis
- Mild papillosis
- Broad, branching rete ridges, sometimes with pseudoepitheliomatous hyperplasia
- The upper epidermis may show koilocytosis with raisinoid nuclei.
- Focal parakeratosis in epidermal invaginations
- Dyskeratotic keratinocytes may be present.
- The dermis shows edema, vascular dilatation and a variable lymphocytic infiltrate.