Clinical Features:

• Proliferative (or "proliferation") nodules are rare benign lesions that develop within congenital nevi, sometimes raising suspicion for melanoma clinically.
• They generally present as smooth-surfaced brown to black papules or nodules, usually less than one centimeter in diameter.
• Ulceration or hemorrhage sometimes occur.
• They tend to gradually regress.

Histologic Features:

• Nodular proliferation of large epithelioid or spindle-shaped melanocytes with abundant cytoplasm and mild pleomorphism
• The cells of the proliferative nodule merge imperceptibly at the margin of the nodule with the cells of the surrounding congenital nevus.
• More than one mitoses per square millimeter are not permitted for the diagnosis of proliferative nodule.

Cases associated with this book:

Congenital nevus with proliferative nodules
Author: Artur Zembowicz M.D. Ph.D.

Conference: Dr. Z's Consultations