Crohn's disease

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • An inflammatory bowel disease which can affect any part of the gastrointestinal tract, from the mouth to the anus.
    • Oral disease takes the form of swelling of the lips, cobblestoning and/or linear ulcers.
    • Perianal disease can present with fistulas, sinus tracts and/or ulceration.
    • Cutaneous lesions occasionally occur at sites distant from the mouth and anus ("metastatic Crohn's disease"), taking the form of nodules and plaques that may ulcerate.  These are most commonly seen in flexural areas, the lower extremities (where they may mimic erythema nodosum) and the penis.
    • Lesions may also occur surrounding an ostomy site in a patient status post colostomy.

    Histologic Features:

    • Noncaseating granulomas with abundant lymphocytes and plasma cells are found throughout the dermis.
    • The granulomatous inflammation often extends into the subcutaneous fat, giving rise to a septal and lobular panniculitis.
    • Granulomatous vasculitis may occur.
    • Genital lesions may show prominent edema.
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    Cases associated with this book:

  • Crohn's disease
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dermpedia Teaching Collection