Sean Klepper M.D.
Artur Zembowicz M.D....
- Cryoglobulins are immunoglobulins that precipitate reversibly at cold temperatures.
- They are associated with a number of neoplastic, autoimmune and infectious conditions, the most common of which is hepatitis C.
- A variety of systemic and cutaneous manifestations may be present as a result of thrombi formed by the precipitated cryoglobulins.
- Cutaneous lesions may include palpable purpura, urticaria-like lesions, livedo reticularis, Raynaud's phenomenon, acrocyanosis, gangrene and ulceration.
- Thrombus-like, pink, cracked material occluding dermal blood vessels and passing into the vessel walls.
- The material stains positive with PAS.
- Erythrocyte extravasation
- Vasculitis is often present in mixed cryoglobulinemia (types II and III), but is typically not present in type I cyroglobulinemia.