Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Cryoglobulins are immunoglobulins that precipitate reversibly at cold temperatures.
    • They are associated with a number of neoplastic, autoimmune and infectious conditions, the most common of which is hepatitis C.
    • A variety of systemic and cutaneous manifestations may be present as a result of thrombi formed by the precipitated cryoglobulins.
    • Cutaneous lesions may include palpable purpura, urticaria-like lesions, livedo reticularis, Raynaud's phenomenon, acrocyanosis, gangrene and ulceration.

    Histologic Features:

    • Thrombus-like, pink, cracked material occluding dermal blood vessels and passing into the vessel walls.
    • The material stains positive with PAS.
    • Erythrocyte extravasation
    • Vasculitis is often present in mixed cryoglobulinemia (types II and III), but is typically not present in type I cyroglobulinemia.
    External Links:

    Cases associated with this book:

  • Cryoglobulinemia
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dermpedia Teaching Collection