Clinical Features:

• Multiple etiologies:
  • Secondary to tissue injury, such as surgery, trauma or infection
  • Secondary to conditions which cause calcification: certain tumors (e.g., pilomatrixoma, BCC, chondroid syringoma), collagen vascular diseases (especially CREST syndrome), childhood dermatomyositis, old scars and scleroderma
  • Primary (osteoma cutis)
  • Miliary osteomas of the face: multiple small, hard papules related to acne scars
  • Nevus of Nanta: melanocytic nevus with osteoma
  • Various inherited disorders: Gardner's syndrome, Albright's hereditar osteodystrophy, alkaptonuria, ochronosis

Histologic Features:

• Dermal or subcutaneous trabeculae of lamellar bone
• Osteoblasts and/or osteoclasts may be present.
• Hematopoiesis is usually abesent from the marrow spaces, but may occasionally be seen.

Cases associated with this book:

Cutaneous ossification
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection