Dermatitis herpetiformis

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:

    • Intensely pruritic vesicular disease, presenting as a symmetrically distributed eruption on the extensor surfaces of extremities of young adults
    • Associated with gluten-sensitive enteropathy

    Histologic Features:

    • Small subepidermal blisters
    • Neutrophilic microabscess within the dermal papillae
    • Superficial perivascular lymphocytic infiltrate
    • Immunofluorescence shows granular deposits of IgA and C3 along the dermal-epidermal junction, localizing to the tips of the dermal papillae.
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