Desmoplastic Spitz nevus

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Also known as: Sclerosing Spitz nevus, desmoplastic nevus

    Clinical Features:

    • Most common on the extremities of adults
    • Presents as a dome-shaped papule or nodule

    Histologic Features:

    • Ill-defined proliferation of large polygonal to spindled melanocytes within a fibrotic dermis, most often with no junctional component
    • The melanocytes often show nesting in the more superficial aspects of the lesion and infiltrate as single cells between the thickened dermal collagen bundles in the deeper aspects (maturation).
    • The melanocytes also tend to become smaller as they go deeper into the dermis.
    • Occasional multinucleated giant cells and pleomorphic cells may be present, especially in the upper portions of the lesion.
    • Mitoses are absent or very rare.

    Cases associated with this book:

  • Desmoplastic Spitz nevus
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Dermpedia Teaching Collection