Clinical Features:

• Typically presents with acute onset following vigorous exercise
• Most commonly involves the extremities: sleeve-like induration with a peau d'orange appearance
• Peripheral eosinophilia is often present.
• Some patients go on to develop a hematopoietic neoplasm.

Histologic Features:

• Lymphoplasmacytic inlammation of the fibrous trabeculae of the subcutaneous fat
• Progressive sclerosis of the fibrous trabeculae and subcutaneous fascia, eventually obliterating the fat lobules
• Similar features are present in morphea profunda and sleroderma, except the sclerosis is centered higher up, at the interface of the dermis and subcutis, rather than in the fascia.
• Additional changes that may sometimes be seen are tissue eosinophilia, mucin deposition and vasculitis.

Cases associated with this book:

Eosinophilic fasciitis
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection