Sean Klepper M.D.
Stephen Lyle, M.D., ...
- Well-circumscribed plaques, most often on the extremities or genitalia, that arise acutely after exposure to the causative drug and are sometimes accompanied by pruritis or burning
- If re-exposure to the same drug occurs, the lesions characteristically recur in the same location.
- Blistering may occur.
- Resolves with postinflammatory hyperpigmentation.
- The most commonly inciting drugs (among many others) are:
- Marked basal cell hydropic degeneration with subepidermal vesiculation in later lesions
- Lymphocyte tagging along the epidermodermal junction
- Individual keratinocyte necrosis
- Pigment incontinence
- Mixed upper dermal inflammatory infiltrate consisting of lymphocytes, histiocytes, neutrophils and eosinophils