Clinical Features:

• White-red nodules, most commonly on the digits and auricles and overlying joints
• Secondary to hyperuricemia

Histologic Features:

• Dermal and subcutaneous deposits of amorphous gray, white or weakly eosinophilic material (tophi) surrounded by palisading granulomas
• If the tissue is alcohol fixed or there is incomplete formalin fixation, the uric acid crystals are visible with polarization as doubly-refractive (yellow when parallel to the condensator and blue when perpendicular to it), needle-shaped crystals.
• The tophi stain positive with von Kossa or, more specifically, de Galantha stains.

Cases associated with this book:

Gout
Author: Artur Zembowicz M.D. Ph.D.

Conference: Dr. Z's Consultations

Gout
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection