Gout

    Clinical Features:

    • White-red nodules, most commonly on the digits and auricles and overlying joints
    • Secondary to hyperuricemia

    Histologic Features:

    • Dermal and subcutaneous deposits of amorphous gray, white or weakly eosinophilic material (tophi) surrounded by palisading granulomas
    • If the tissue is alcohol fixed or there is incomplete formalin fixation, the uric acid crystals are visible with polarization as doubly-refractive (yellow when parallel to the condensator and blue when perpendicular to it), needle-shaped crystals.
    • The tophi stain positive with von Kossa or, more specifically, de Galantha stains.
    External Links:

     

    Cases associated with this book:

  • Gout
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Gout
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection