Clinical Features:

• Disease affecting bone marrow transplant recipients in which graft leukocytes attack various organs in the transplant recipient
• The skin is the first and most often involved organ. 
• Skin manifestations include early erythematous macules and patches which may progress to generalized erythroderma and blistering.

Histologic Features:

• GVHD is graded according to the following scheme.  The minimum criterion for a definitive diagnosis is grade 2.
  
  • Grade 0: No pathologic change
  • Grade 1: Basal vacuolization
  • Grade 2: Basal vacuolization, necrotic keratinocytes, dermal inflammation
  • Grade 3: Confluence of basal vacuoles
  • Grade 4: Separation of epidermis from dermis

Cases associated with this book:

Graft-versus-host disease
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection