Graft-vs-host reaction

    Clinical Features:

    • Disease affecting bone marrow transplant recipients in which graft leukocytes attack various organs in the transplant recipient
    • The skin is the first and most often involved organ. 
    • Skin manifestations include early erythematous macules and patches which may progress to generalized erythroderma and blistering.

    Histologic Features:

    • GVHD is graded according to the following scheme.  The minimum criterion for a definitive diagnosis is grade 2.
      • Grade 0: No pathologic change
      • Grade 1: Basal vacuolization
      • Grade 2: Basal vacuolization, necrotic keratinocytes, dermal inflammation
      • Grade 3: Confluence of basal vacuoles
      • Grade 4: Separation of epidermis from dermis
    External Links:

    Cases associated with this book:

  • Graft-versus-host disease
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection