Halo nevus

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Also known as: leukoderma acquisitum centrifugum, Sutton's nevus, perinevoid vitiligo, perinevoid leukoderma

    Clinical Features:

    • Term for a melanocytic nevus that is surrounded by a halo of depigmentation that corresponds to a dense mononuclear infiltrate seen histologically
    • Any type of melanocytic nevus may develop this reaction.
    • Most common in patients younger than 20 years, with a predilection for the upper back
    • Associated with vitiligo and melanoma
    • Frequently completely regress
    • Often multiple
    • Presents as a central nevus with overlying scaling or crusting surrounded by a well-circumscribed ring of hypo- or depigmented skin

    Histologic Features:

    • Junctional, compound or intradermal nevus surrounded and intimately associated with a dense infiltrate of lymphocytes and histiocytes
    • The inflammatory infiltrate is often so dense that it largely obscures the nevus cells, making them difficult to appreciate on H&E.
    • Apoptotic nevus cells are often present near the dermal-epidermal junction, and scattered dermal cells with lesser degrees of damage may show eosinophilic cytoplasm and enlarged and even pleomorphic nuclei.
    • The peripheral aspect of the nevus, which corresponds clinically to the halo, shows decreased to absent balilar melanocytes and melanin.
    External Links:

    Cases associated with this book:

  • Halo nevus with regression
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 11-year-old girl with brown-tan papules on her back and chest
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations