Sean Klepper M.D.
Artur Zembowicz M.D....
Also known as: leukoderma acquisitum centrifugum, Sutton's nevus, perinevoid vitiligo, perinevoid leukoderma
- Term for a melanocytic nevus that is surrounded by a halo of depigmentation that corresponds to a dense mononuclear infiltrate seen histologically
- Any type of melanocytic nevus may develop this reaction.
- Most common in patients younger than 20 years, with a predilection for the upper back
- Associated with vitiligo and melanoma
- Frequently completely regress
- Often multiple
- Presents as a central nevus with overlying scaling or crusting surrounded by a well-circumscribed ring of hypo- or depigmented skin
- Junctional, compound or intradermal nevus surrounded and intimately associated with a dense infiltrate of lymphocytes and histiocytes
- The inflammatory infiltrate is often so dense that it largely obscures the nevus cells, making them difficult to appreciate on H&E.
- Apoptotic nevus cells are often present near the dermal-epidermal junction, and scattered dermal cells with lesser degrees of damage may show eosinophilic cytoplasm and enlarged and even pleomorphic nuclei.
- The peripheral aspect of the nevus, which corresponds clinically to the halo, shows decreased to absent balilar melanocytes and melanin.