Intravascular lymphoma

    Clinical Features:

    • Disease may be limited to the skin, or it may be a manifestation of systemic disease.
    • Presents with indurated erythematous or violaceous patches or plaques
    • Commonly affects the trunk and thighs

    Histologic Features:

    • Large atypical lymphocytes, often with prominent nucleoli, filling distended blood vessels within the dermis and subcutis
    • The neoplastic lymphocytes are positive for pan-B-cell markers.
    • CD5 is sometimes positive.
    • A rare T-cell variant has also been described.