Sean Klepper M.D.
Artur Zembowicz M.D....
Also known as: parapsoriasis en grandes plaques
- Controversial relationship with mycosis fungoides: some consider it an inflammatory process that may progress to MF, whereas others believe it to be part of the spectrum of presentations of MF
- Large (>10 cm), scaly, erythematous patches and plaques, most commonly on the buttocks, flexural surfaces and breasts
- A chronic disease most often affecting middle-aged individuals
- May progress to mycosis fungoides, with thickening of the plaques
- Early lesions show only a superficial perivascular lymphocytic infiltrate.
- As the lesion progresses, the epidermis develops mild irregular acanthosis with mounds of parakeratosis.
- In chronic lesions, there is a dense bandlike lymphocytic infiltrate, dermal fibrosis, basal vacuolar change and pigment incontinence.
- In all stages, the lymphocytic infiltrate is composed of monoclonal T-cells.