Also known as: parapsoriasis en grandes plaques

Clinical Features:

• Controversial relationship with mycosis fungoides: some consider it an inflammatory process that may progress to MF, whereas others believe it to be part of the spectrum of presentations of MF
• Large (>10 cm), scaly, erythematous patches and plaques, most commonly on the buttocks, flexural surfaces and breasts
• A chronic disease most often affecting middle-aged individuals
• May progress to mycosis fungoides, with thickening of the plaques

Histologic Features:

• Early lesions show only a superficial perivascular lymphocytic infiltrate.
• As the lesion progresses, the epidermis develops mild irregular acanthosis with mounds of parakeratosis.
• In chronic lesions, there is a dense bandlike lymphocytic infiltrate, dermal fibrosis, basal vacuolar change and pigment incontinence.
• In all stages, the lymphocytic infiltrate is composed of monoclonal T-cells.

Cases associated with this book:

Large plaque parapsoriasis
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection