Lichen planus pemphigoides

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Controversial entity with features resembling both lichen planus and bullous pemphigoid

    Clinical Features:

    • Primarily a disease of adults
    • Patients present with lesions identical to those of lichen planus in conjunction with tense bullae identical to those seen in bullous pemphigoid.

    Histologic Features:

    • Biopsies of lichen-planus like lesions (indistinguishable from lichen planus):
      • Hyperkeratosis
      • Hypergranulosis (often wedge shaped)
      • Acanthosis with saw-tooth rete ridges
      • Colloid bodies
      • Lichenoid lymphocytic infiltrate with exocytosis
    • Biopsies of bullous pemphigoid-like lesions:
      • Subepidermal blister
      • Papillary dermal edema
      • Perivascular lymphocytic infiltrate, sometimes with eosinophils
      • Immunofluorescence shows liner IgG and C3 along the dermal-epidermal junction.
    External Links:

    Cases associated with this book:

  • Lichen planus pemphigoides
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Teaching Collection