Sean Klepper M.D.
Artur Zembowicz M.D....
Controversial entity with features resembling both lichen planus and bullous pemphigoid
- Primarily a disease of adults
- Patients present with lesions identical to those of lichen planus in conjunction with tense bullae identical to those seen in bullous pemphigoid.
- Biopsies of lichen-planus like lesions (indistinguishable from lichen planus):
- Hypergranulosis (often wedge shaped)
- Acanthosis with saw-tooth rete ridges
- Colloid bodies
- Lichenoid lymphocytic infiltrate with exocytosis
- Biopsies of bullous pemphigoid-like lesions:
- Subepidermal blister
- Papillary dermal edema
- Perivascular lymphocytic infiltrate, sometimes with eosinophils
- Immunofluorescence shows liner IgG and C3 along the dermal-epidermal junction.