Controversial entity with features resembling both lichen planus and bullous pemphigoid

Clinical Features:

• Primarily a disease of adults
• Patients present with lesions identical to those of lichen planus in conjunction with tense bullae identical to those seen in bullous pemphigoid.

Histologic Features:

• Biopsies of lichen-planus like lesions (indistinguishable from lichen planus):
  • Hyperkeratosis
  • Hypergranulosis (often wedge shaped)
  • Acanthosis with saw-tooth rete ridges
  • Colloid bodies
  • Lichenoid lymphocytic infiltrate with exocytosis
• Biopsies of bullous pemphigoid-like lesions:
  • Subepidermal blister
  • Papillary dermal edema
  • Perivascular lymphocytic infiltrate, sometimes with eosinophils
  • Immunofluorescence shows liner IgG and C3 along the dermal-epidermal junction.

Cases associated with this book:

Lichen planus pemphigoides
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection