Lichen sclerosus

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:

    • Indurated white plaques, most commonly on the vulva and perianal skin of women
    • Slightly increased risk of squamous cell carcinoma

    Histologic Features:

    • Epidermal atrophy, often with hyperkeratosis
    • Homogenized, hyalinized, pale eosinophilic superficial dermis with vascular ectasia
    • Early superficial perivascular lymphocytic infiltrate progressing to a lichenoid lymphocytic infiltrate beneath the homogenized zone of upper dermis in older lesions
    • Interface change, rarely with subepidermal blister formation
    • Follicular plugging
    External Links: