Clinical Features:

• Indurated white plaques, most commonly on the vulva and perianal skin of women
• Slightly increased risk of squamous cell carcinoma

Histologic Features:

• Epidermal atrophy, often with hyperkeratosis
• Homogenized, hyalinized, pale eosinophilic superficial dermis with vascular ectasia
• Early superficial perivascular lymphocytic infiltrate progressing to a lichenoid lymphocytic infiltrate beneath the homogenized zone of upper dermis in older lesions
• Interface change, rarely with subepidermal blister formation
• Follicular plugging

Cases associated with this book:

Lichen sclerosus
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection

37 year old woman with whitish itchy area on the vulva
Author: Erika M Brewer

Conference: Tufts First Year Medical Student's Dermatopathology Elective