Lupus panniculitis

    Also known as: lupus profundus

    Clinical Features:

    • Uncommon manifestation of systemic lupus erythematosus, or may occasionally be seen in the absence of the disease
    • Possible relationship with subcutaneous lymphoma
    • Presents with multiple indurated subcutaneous nodules, most commonly on the proximal extremities, but may occur elsewhere
    • The overlying skin may show a variety of changes, including discoid lupus erythematosus, poikiloderma or ulceration.

    Histologic Features:

    • The overlying skin may or may not show features of systemic lupus erythematosus or discoid lupus erythematosus.
    • Septal and lobular panniculitis with:
      • Lymphocytic inflammation, often with lymphoid aggregates and/or follicles, at the periphery of the fat lobules
      • Fequent plasma cells
      • Hyaline necrosis of the fat lobules, often with karyorrhectic debris and mucin deposition
      • Hyalinization of the adipose tissue, septa and blood vessels
      • Often lymphocytic vasculopathy or frank vasculitis with fibrin thrombi
      • Less characteristic changes that may sometimes be present include: thickening of the septa, septal granulomas and eosinophils.
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    Cases associated with this book:

  • Lupus panniculitis
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Teaching Collection