Clinical Features:

• Chronic relapsing disease characterized by papulonodular lesions that spontaneously regress, leaving hyper- or hypopigmented scars
• Most commonly on the trunk and extremitites of adults
• Some patients eventually develop a secondary lymphoma.

Histologic Features:

• LyP type A lesions (most common):
  • Wedge-shaped dermal infiltrate that often extends into the subcutaneous fat
  • Epidermotropism
  • The infiltrate is composed of mitotically active medium-sized to large pleomorphic cells admixed with numerous neutrophils and eosinophils
• LyP type B (rare):
  • Epidermotropic infiltrate of amall to medium-sized cells indistinguishable from mycosis fungoides
• LyP type C:
  • Cohesive sheets of tumor cells with few admixed neutrophils
• Helper T-cell phenotype (CD3+, CD4+, CD5+, CD8-) with characteristic positivity for CD30 and TIA-1

Cases associated with this book:

Lymphomatoid papulosis
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection