Lymphomatoid papulosis

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Chronic relapsing disease characterized by papulonodular lesions that spontaneously regress, leaving hyper- or hypopigmented scars
    • Most commonly on the trunk and extremitites of adults
    • Some patients eventually develop a secondary lymphoma.

    Histologic Features:

    • LyP type A lesions (most common):
      • Wedge-shaped dermal infiltrate that often extends into the subcutaneous fat
      • Epidermotropism
      • The infiltrate is composed of mitotically active medium-sized to large pleomorphic cells admixed with numerous neutrophils and eosinophils
    • LyP type B (rare):
      • Epidermotropic infiltrate of amall to medium-sized cells indistinguishable from mycosis fungoides
    • LyP type C:
      • Cohesive sheets of tumor cells with few admixed neutrophils
    • Helper T-cell phenotype (CD3+, CD4+, CD5+, CD8-) with characteristic positivity for CD30 and TIA-1

    Cases associated with this book:

  • Lymphomatoid papulosis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection