Membranous lipodystrophy

    Also known as: lipodermatosclerosis, hypodermitis sclerodermiformis, lipomembranous fat necrosis, lipomembranous change in chronic panniculitis, stasis-associated lipomembranous panniculitis, stasis-related sclerosing panniculitis

    Clinical Features:

    • Secondary to venous stasis, leading to fat necrosis and fibrosis
    • Most commonly affects adult women.
    • Presents with erythematous indurated plaques on the distal lower extremities, described as having an "inverted bottle" appearance

    Histologic Features:

    • The overlying skin usually shows changes of stasis dermatitis.
    • Septal and lobular panniculitis with early perivascular lymphycytic infiltrates
    • Ischemic fat necrosis with:
      • Early pallor of adipocytes with loss of nuclei, karyorrhexis, hemorrhage and hemosiderin deposition
      • Progressive fibrosis of the septa with fibrous obliteration of the fat lobules
      • Progressive fat necrosis with formation of microcysts and lipomembranous change (cystic spaces lined by feathery eosinophilic membranes said to resemble parasitic cuticles, PAS positive)

    External Links:

    Cases associated with this book:

  • Membranous lipodystrophy
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection