Morphea (localized scleroderma)

    Also known as: localized scleroderma, circumscribed scleroderma

    Clinical Features:
    Clinical Features:

    • Represents a localized form of scleroderma
    • Patients may rarely go on to develop systemic scleroderma.
    • Most common in young to middle-aged women
    • Controversial relationship with Borrelia burgdoferi
    • Presents as indurated whitish plaques with a peripheral "lilac ring" rim.

    Histologic Features:

    • Early lesions:
      • Sclerosis of the reticular dermis
      • Superficial and deep perivascular lymphocytic infiltrate
    • Later lesions:
      • Increasing sclerosis of the dermis with hyalinization and extension of the sclerosis into the subcutaneous fat
      • Atrophy and dropout of adnexal structures with "entrapment" of eccrine glands between sclerotic collagen bundles
      • Sometimes nodular collections of lymphocytes at the the dermal-subcutaneous junction
      • The epidermis is normal or atrophic.
    External Links:

     

    Cases associated with this book:

  • Early deep dermal morphea
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Morphea
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection