Multiple lentigines

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Small, well-circumscibed, brown macule resulting from a benign increase in the number of melanocytes and melanin production
    • The finding of widespread lentigines is known as lentiginosis profusa.
    • Multiple lentigines can be seen in several syndromes:
      • LEOPARD: Lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonary stenosis, abnormal genitalia, retardation of growth, deafness
      • LAMB: Lentigines, atrial myxomas, cutaneous papular myxomas, blue nevi
      • Peutz-Jeghers syndrome
    • Lengigines may eventually give progress to melanocytic nevi.

    Histologic Features:

    • Increased density of basilar melanocytes compared to adjacent uninvolved skin
    • Elongation of the rete ridges with a club-shaped appearance
    • Hyperpigmentation of the basal epidermis, sometimes extending into the upper epidermis, often most pronounced at the tips of the rete ridges

    Cases associated with this book:

  • Lentigo simplex
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection