Clinical Features:

• Small, well-circumscibed, brown macule resulting from a benign increase in the number of melanocytes and melanin production
• The finding of widespread lentigines is known as lentiginosis profusa.
• Multiple lentigines can be seen in several syndromes:
  • LEOPARD: Lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonary stenosis, abnormal genitalia, retardation of growth, deafness
  • LAMB: Lentigines, atrial myxomas, cutaneous papular myxomas, blue nevi
  • Peutz-Jeghers syndrome
• Lengigines may eventually give progress to melanocytic nevi.

Histologic Features:

• Increased density of basilar melanocytes compared to adjacent uninvolved skin
• Elongation of the rete ridges with a club-shaped appearance
• Hyperpigmentation of the basal epidermis, sometimes extending into the upper epidermis, often most pronounced at the tips of the rete ridges

Cases associated with this book:

Lentigo simplex
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection