Myxoid liposarcoma

    Clinical Features:

    • More common in the deep soft tissues; subcutaneous examples are rare
    • Most commonly seen in the lower limb of adults
    • Tends to recur
    • Metastases occur in approximately one third of cases
    • Round cell liposarcoma is part of the spectrum of myxoid liposarcoma, and the presence of a round cell component is an adverse prognostic marker.

    Histologic Features:

    • Uniform stellate to spindled cells in a myxoid background
    • The cells contain small vacuoles with rare mitoses
    • Occasional lipoblasts can be seen, most commonly at the periphery of the tumor.
    • The most characteristic and specific diagnostic feature is the universally present network of abundant small, curvilinear, branching capillaries, described as having a "chicken wire" or "crow's foot" appearance.  The absence of these vessels effectively rules out the diagnosis of myxoid liposarcoma.
    • Pools of mucin, sometimes resembling lymphangioma, are often present.
    • Round cell change is the term used for more cellular areas with round to oval hyperchromatic nuclei and high nuclear:cytoplasmic ratios
      • Round cell change is associated with a more aggressive course and less favorable prognosis.
      • Tumors with both myxoid and round cell areas are known as either combined myxoid and round cell liposarcoma or high-grade myxoid liposarcoma.
      • Pure round cell liposarcomas are extremely rare in the subcutis.

    Cases associated with this book:

  • Myxoid liposarcoma
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection