Neurofibroma, nos

    Clinical Features:

    • Benign tumor of nerve sheath origin
    • Most common in young adults
    • May arise on any area of the skin
    • Presents as a polypoid or nodular lesion
    • Usually solitary, but multiple lesions are seen in neurofibromatosis type I, in which ordinary neurofibromas are the most common, but plexiform neurofibromas are nearly pathognomonic
    • Cured by simple excision, with rare recurrences
    • Malignant transformation occasionally occurs.

    Histologic Features:

    • Relatively well-circumscribed dermal or subcutaneous lesion
    • Composed of a loose proliferation of spindle cells with wavy nuclei in a fibrillar, collagenous or myxoid stroma
    • Scattered inflammatory cells, including mast cells
    • Hyalinization of the collagen may sometimes occur.
    • Mitotic activity in a neurofibroma in a patient with neurofibromatosis type I is considered evidence of malignancy.

    Cases associated with this book:

  • Neurofibroma
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection