Nevus of Ota and Ito

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:

    • Both of these lesions present as bluish macules which are present at birth or shortly thereafter.  They are believed to represent hamartomas, and are distinguished only on their site of presentation.
    • The nevus of Ota (nevus fuscoceruleus ophthalmaxillaris) is present on the upper face in the distribution of the first two branches of the trigeminal nerve.  The eye and/or nasal or oral mucosa may also be involved.
    • The nevus of Ito (nevus fuscoceruleus acromiodeltoideus) is located in the supraclavicular, scapular or deltoid regions unilaterally.

    Histologic Features:

    • The nevus of Ota and the nevus of Ito show identical histologic features.
    • There are scattered dendritic melanocytes within the upper dermis, more dense than in Mongolian spot, without disruption of the dermal collagen.
    • The dendritic melanocytes contain fine melanin granules.
    • The dendritic melanocytes may aggregate around skin appendages, blood vessels and nerves.
    External Links:

    Cases associated with this book:

  • Nevus of Ota
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Dermpedia Teaching Collection