Nodular fascitis

    Clinical Features:

    • Reactive process of unknown etiology
    • Most common on the limbs and trunk of young to middle-aged adults
    • Presents as a rapidly growing, painful subcutaneous nodule
    • Local recurrence uncommonly occurs.

    Histologic Features:

    • Well-circumscribed proliferation of interlacing fascicles of plump spindle cells ("tissue culture-like fibroblasts")
    • Mitotically active
    • Loose myxoid and collagenous background, highly variable in degree of collagenization and myxoid change
    • Multiple branching thin-walled blood vessels are interspersed throughout the lesion.
    • Focal hemorrhage and lymphocytic inflammation are often seen.
    • Foamy histiocytes and osteoclast-like giant cells are sometimes present.
    • Immunohistochemically, the spindle cells are positive for MSA and calponin, but negative for desmin, consistent with myofibroblasts.
    External Links:

    Cases associated with this book:

  • Nodular fasciitis
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection