Orofacial granulomatosis

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Also known as: cheilitis granulomatosa, Miescher-Melkersson-Rosenthal syndrome, granulomatous cheilitis

    Clinical Features:

    • Presents with lip swelling, sometimes with more extensive facial involvement, particularly affecting the eyelids
    • The penis and vulva can be affected by similar lesions.
    • Miescher-Melkersson-Rosenthal syndrome displays the triad of lep swelling, unilateral facial paralysis and a furrowed tongue.

    Histologic Features:

    • Non-necrotizing, poorly formed "naked" granulomas within the dermis
    • Marked dermal edema
    • Dilated dermal lymphatics
    • Perivascular dermal lymphoplasmacytic infiltrate
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    Cases associated with this book:

  • Orofacial granulomatosis
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Dermpedia Teaching Collection