Sean Klepper M.D.
Artur Zembowicz M.D....
- An eruption which occurs minutes to a few days following ultraviolet light exposure, and which resolves within seven to ten days
- Predilection for the upper extremities and head and neck, with an adult female predominance
- Presents as pruritic erythematous papules, vesicles and plaques.
- Marked dermal edema
- An early upper dermal perivascular lymphocytic infiltrate which progresses to a superficial and deep perivascular infiltrate with lymphocytes, eosinophils and neutrophils, often with perivascular cuffing
- Upper dermal vascular ectasia and endothelial swelling
- Epidermal pathology ranges from no changes to vacuolar interface change and/or spongiosis with lymphocytic exocytosis, vesiculation, acanthosis, parakeratosis and occasionally even epidermal necrosis.
- Direct immunofluorescence shows perivascular IgM and C3 deposition.