Polymorphous light eruption

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • An eruption which occurs minutes to a few days following ultraviolet light exposure, and which resolves within seven to ten days
    • Predilection for the upper extremities and head and neck, with an adult female predominance
    • Presents as pruritic erythematous papules, vesicles and plaques.

    Histologic Features:

    • Marked dermal edema
    • An early upper dermal perivascular lymphocytic infiltrate which progresses to a superficial and deep perivascular infiltrate with lymphocytes, eosinophils and neutrophils, often with perivascular cuffing
    • Upper dermal vascular ectasia and endothelial swelling
    • Epidermal pathology ranges from no changes to vacuolar interface change and/or spongiosis with lymphocytic exocytosis, vesiculation, acanthosis, parakeratosis and occasionally even epidermal necrosis.
    • Direct immunofluorescence shows perivascular IgM and C3 deposition.
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    Cases associated with this book:

  • Polymorphous light eruption
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dermpedia Teaching Collection