Clinical Features:

• Seen in patients with treated hyperthyroidism
• Elevated knobby plaques or nodules with a waxy surface on the shins and occasionally dorsal feet 

Histologic Features:

• Expansion of the dermis, most prominently the deeper dermis, by abundant mucin separating the collagen bundles (strongly Alcian blue positive)
• Fibroblasts appear to float in edematous areas.
• Lymphatic dilatation may be present.
• Fibrosis of the deep dermis and subcutis in older lesions

External Links:

• Wikipedia

Cases associated with this book:

Pretibial myxedema
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection