Also known as: CD30+ pleomorphic large T-cell lymphoma

Clinical Features:

• Solitary or multiple nodular tumors, which may ulcerate, typically confined to one area of the body
• Predominantly affects middle-aged individuals, with a 2:1 male-to-female ratio
• May spontaneously regress

Histologic Features:

• Nodular dermal infiltrate which may extend into the subcutis
• Cytologically, the neoplastic cells are large, highly atypical cells with very irregular, pleomorphic nuclei with dispersed chromatin and one to several nucleoli and abundant pale to eosinophilc cytoplasm.
• Scattered reactive small mature lymphocytes and eosinophils are present admixed with the tumor cells.
• Occasionally, there may be abundant neutrophils which obscure the tumor cells.
• Immunophenotypically, the neoplastic cells are positive for pan-T-cell markers, often with loss of one or more marker, and characteristically positive for CD30.
• In contrast to systemic ALCL, EMA, ALK and t(2;5) are absent.

Cases associated with this book:

Primary cutaneous anaplastic large cell lymphoma
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection