Primary cutaneous anaplastic large cell lymphoma

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Also known as: CD30+ pleomorphic large T-cell lymphoma

    Clinical Features:

    • Solitary or multiple nodular tumors, which may ulcerate, typically confined to one area of the body
    • Predominantly affects middle-aged individuals, with a 2:1 male-to-female ratio
    • May spontaneously regress

    Histologic Features:

    • Nodular dermal infiltrate which may extend into the subcutis
    • Cytologically, the neoplastic cells are large, highly atypical cells with very irregular, pleomorphic nuclei with dispersed chromatin and one to several nucleoli and abundant pale to eosinophilc cytoplasm.
    • Scattered reactive small mature lymphocytes and eosinophils are present admixed with the tumor cells.
    • Occasionally, there may be abundant neutrophils which obscure the tumor cells.
    • Immunophenotypically, the neoplastic cells are positive for pan-T-cell markers, often with loss of one or more marker, and characteristically positive for CD30.
    • In contrast to systemic ALCL, EMA, ALK and t(2;5) are absent.

    Cases associated with this book:

  • Primary cutaneous anaplastic large cell lymphoma
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection