Sean Klepper M.D.
Stephen Lyle, M.D., ...
Also known as: CD30+ pleomorphic large T-cell lymphoma
- Solitary or multiple nodular tumors, which may ulcerate, typically confined to one area of the body
- Predominantly affects middle-aged individuals, with a 2:1 male-to-female ratio
- May spontaneously regress
- Nodular dermal infiltrate which may extend into the subcutis
- Cytologically, the neoplastic cells are large, highly atypical cells with very irregular, pleomorphic nuclei with dispersed chromatin and one to several nucleoli and abundant pale to eosinophilc cytoplasm.
- Scattered reactive small mature lymphocytes and eosinophils are present admixed with the tumor cells.
- Occasionally, there may be abundant neutrophils which obscure the tumor cells.
- Immunophenotypically, the neoplastic cells are positive for pan-T-cell markers, often with loss of one or more marker, and characteristically positive for CD30.
- In contrast to systemic ALCL, EMA, ALK and t(2;5) are absent.