Primary cutaneous B-cell lymphoma, leg type.

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Aggressive lymphoma seen on the lower legs of elderly patients, with a female predominance
    • Presents as one or multiple red-brown or violaceous tumors
    • Five-year survival of approximately 60%

    Histologic Features:

    • Diffuse dermal and subcuataneous infiltrate of atypical large lymphocytes with prominent nucleoli resembling immunoblasts or centroblasts
    • Highly mitotically active
    • A starry sky appearance may sometimes be seen.
    • Positive for pan-B-cell markers, sometimes with loss of one or more markers
    • bcl-2 is often positive, and CD10 and bcl-6 are variable
    • Immunoglobulin light chain restriction can be demonstrated immunohistochemically in some cases.