Primary cutaneous B-cell lymphoma, leg type.
Sean Klepper M.D.
Artur Zembowicz M.D....
- Aggressive lymphoma seen on the lower legs of elderly patients, with a female predominance
- Presents as one or multiple red-brown or violaceous tumors
- Five-year survival of approximately 60%
- Diffuse dermal and subcuataneous infiltrate of atypical large lymphocytes with prominent nucleoli resembling immunoblasts or centroblasts
- Highly mitotically active
- A starry sky appearance may sometimes be seen.
- Positive for pan-B-cell markers, sometimes with loss of one or more markers
- bcl-2 is often positive, and CD10 and bcl-6 are variable
- Immunoglobulin light chain restriction can be demonstrated immunohistochemically in some cases.