Primary cutaneous follicle center lymphoma.

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Presents as solitary or grouped papules, plaques or tumors
    • Most common on the scalp, forehead and back
    • Good prognosis

    Histologic Features:

    • Nodular or diffuse infiltrate occupying the entire dermis and sometimes extending into the subcuataneous fat
    • Follicle formation may or may not be seen in the nodular pattern, and is absent from the diffuse pattern.
    • The infiltrate consists of a mixture of centrocytes (small lymphocytes with cleaved nuclei) and centroblasts (large lymphocytes with prominent nucleoli), with the centrocytes typically predominating in the nodular pattern.
    • If follicle formation is present, the neoplastic follicles are surrounded by reactive T-cells and histiocytes, with foci of interfollicular neoplastic B-cells.
    • The diffuse pattern may resemble diffuse large B-cell lymphoma, but the prognosis remains excellent, and the diagnosis should still be follicle center lymphoma.
    • The neoplastic lymphocytes stain for pan-B-cell markers and usually for bcl-6.
    • CD10 may or not be positive, in contrast to systemic follicular lymphoma, in which it is positive.
    • Also in contrast to systemic follicular lymphoma, the (14;18) translocation is almost always absent.

    Cases associated with this book:

  • Primary cutaneous follicle center lymphoma
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection