Pustular psoriasis

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Occurs in generalized and localized forms.
    • Generalized pustular psoriasis (of Zumbusch):
      • Acute eruption of small pustules on the trunk and extremities following a prodrome of fever
      • The skin surrounding the pustules is erythematous
      • The episodes of fever and pustulation are typically recurrent and are accompanied by systemic symptoms.
      • May be idiopathic or secondary to a variety of triggers, such as viral or streptococcal infection, cessation of corticosteroid therapy, pregnancy, hypocalcemia or phototherapy.
    • Localized (mixed) pustular psoriasis:
      • Development of pustules on pre-existing psoriatic plaques
      • Most often occurs in acute flares or following treatment
    • Palmoplantar pustulosis: See separate textbook entry.

    Histologic Features:

    • Intraepidermal macropustules with accompanying keratinocyte necrosis
    • The classic features of psoriasis are often poorly developed, unless the lesion has arisen on the background of a pre-existing psoriatic lesion.
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    Cases associated with this book:

  • Pustular psoriasis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection