Pyoderma gangrenosum

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • A neutrophilic dermatosis with a variety of clinical presentations
    • The classic presentation is that of tender nodules that form ulcers with undermined rolled edges.
    • May be a primary disorder or occur secondary to a variety of systemic diseases, such as inflammatory bowel disease, connective tissue disease or a hematopoietic malignancy.

    Histologic Features:

    • Marked diffuse dermal neutrophilic infiltrate (deeper and more pronounced than in Sweet's syndrome) with a variable lesser infiltrate of lymphocytes and histiocytes
    • Vasculitis may or may not be present.
    • Sometimes epidermal ulceration and/or necrosis
    • Occasional granulomatous inflammation
    • The findings are nonspecific and the diagnosis is made primarily on clinical grounds.
    External Links:

    Cases associated with this book:

  • Pyoderma gangrenosum
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection