Sean Klepper M.D.
Artur Zembowicz M.D....
- A neutrophilic dermatosis with a variety of clinical presentations
- The classic presentation is that of tender nodules that form ulcers with undermined rolled edges.
- May be a primary disorder or occur secondary to a variety of systemic diseases, such as inflammatory bowel disease, connective tissue disease or a hematopoietic malignancy.
- Marked diffuse dermal neutrophilic infiltrate (deeper and more pronounced than in Sweet's syndrome) with a variable lesser infiltrate of lymphocytes and histiocytes
- Vasculitis may or may not be present.
- Sometimes epidermal ulceration and/or necrosis
- Occasional granulomatous inflammation
- The findings are nonspecific and the diagnosis is made primarily on clinical grounds.