Clinical Features:

• A neutrophilic dermatosis with a variety of clinical presentations
• The classic presentation is that of tender nodules that form ulcers with undermined rolled edges.
• May be a primary disorder or occur secondary to a variety of systemic diseases, such as inflammatory bowel disease, connective tissue disease or a hematopoietic malignancy.

Histologic Features:

• Marked diffuse dermal neutrophilic infiltrate (deeper and more pronounced than in Sweet's syndrome) with a variable lesser infiltrate of lymphocytes and histiocytes
• Vasculitis may or may not be present.
• Sometimes epidermal ulceration and/or necrosis
• Occasional granulomatous inflammation
• The findings are nonspecific and the diagnosis is made primarily on clinical grounds.

Cases associated with this book:

Pyoderma gangrenosum
Author: Artur Zembowicz M.D. Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection