Reactive perforating collagenosis

    Clinical features:

    • Rare genetic disorder. 
    • Characterized by hyperkeratotic papules following minor trauma, most commonly on the ams and hands.


    • Hyperkertotic plug "perforating" the epidermis
    • The plug and subjacent dermis contain collagen fibers and inflammatory cells: macrophages, giant cells, lymphocytes and especially neutrophils.
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    Cases associated with this book:

  • Reactive perforating collagenosis
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Teaching Collection