Relapsing polychondritis

    Clinical Features:

    • A chronic relapsing inflammatory disease most often involving the ears and nose
    • Associated with polyarthritis, ocular inflammation and chondritis of the respiratory tract and cardiac valves
    • Mortality rate as high as 25 percent

    Histologic Features:

    • Mixed inflammatory infiltrate consisting of lymphocytes, neutrophils and plasma cells in the dermis adjacent to deep subcutaneous cartilage
    • Vacuolization and pyknosis of chondrocytes with eventual decrease in the basophilia of the cartilage
    • Destruction of elastic fibers within the cartilage is seen on elastic stain.
    • Old lesions show replacement of chondrocytes with fibrous tissue.

    Cases associated with this book:

  • Scottsdale 2012 Didactic Session VIII Case Vignette 40
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection