Clinical Features:

• Seen in approximately 20 percent of patients with rheumatoid arthritis
• Believed to be secondary to an immune complex-mediated vasculitis
• Cutaneous and visceral (lung, heart, GI tract) nodules may occur.
• Cutaneous nodules are typically seen over joints, particularly the elbow and knuckles, as well as over the Achilles' tendon and sole.

Histologic Features:

• Palisading granulomas surrounding degenerative collagen ("necrobiosis") and fibrinoid necrosis, without mucin, within the deep dermis and subcutis
• Vasculitis may or may not be present.

Cases associated with this book:

Rheumatoid nodule
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection

Rheumatoid nodule
Author: Stephen Lyle, M.D., Ph.D.

Conference: Dermpedia Teaching Collection