Sean Klepper M.D.
Stephen Lyle, M.D., ...
- Seen in approximately 20 percent of patients with rheumatoid arthritis
- Believed to be secondary to an immune complex-mediated vasculitis
- Cutaneous and visceral (lung, heart, GI tract) nodules may occur.
- Cutaneous nodules are typically seen over joints, particularly the elbow and knuckles, as well as over the Achilles' tendon and sole.
- Palisading granulomas surrounding degenerative collagen ("necrobiosis") and fibrinoid necrosis, without mucin, within the deep dermis and subcutis
- Vasculitis may or may not be present.