Rheumatoid nodule

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:

    • Seen in approximately 20 percent of patients with rheumatoid arthritis
    • Believed to be secondary to an immune complex-mediated vasculitis
    • Cutaneous and visceral (lung, heart, GI tract) nodules may occur.
    • Cutaneous nodules are typically seen over joints, particularly the elbow and knuckles, as well as over the Achilles' tendon and sole.

    Histologic Features:

     

    • Palisading granulomas surrounding degenerative collagen ("necrobiosis") and fibrinoid necrosis, without mucin, within the deep dermis and subcutis
    • Vasculitis may or may not be present.
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    Cases associated with this book:

  • Rheumatoid nodule
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Dermpedia Teaching Collection
  • Rheumatoid nodule
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection