Sarcoidal granulomas

    Article Contributors: 
    Sean Klepper M.D.

    Sarcoidal granuloma (or "naked" granuloma) is a term used for a granuloma composed of epithelioid histiocytes with little or no rim of surrounding lymphocytes, as opposed to tuberculoid granulomas, in which such a rim is classically present.  There is some utility in making this distinction, as it can guide one's approach in forming a differential diagnosis, but it is important to not rely too heavily on the type of granulomas present in a lesion, since the distinction is not completely reliable: diseases which traditionally present with sarcoidal granulomas can sometimes show tuberculoid granulomas and vice versa.