Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:


    • Systemic granulomatous disease of unknown etiology, affecting multiple organ systems
    • Most common in black women
    • Approximately 25% of patients have cutaneous involvement, most commonly presenting as violaceous nodules, particularly on the face.

    Histologic Features:

    • Normally, non-necrotizing granulomas are distributed throughout the dermis.
    • The granulomas are often surrounded by a lymphocytic infiltrate.
    • If the subcutis is involved, caseation may sometimes be seen.
    • Asteroid bodies, Shaumann bodies and Hamazaki-Wasserman bodies may be seen, but are nonspecific.

    External Links:

    Cases associated with this book:

  • Sarcoidosis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection