Sean Klepper M.D.
Artur Zembowicz M.D....
- Systemic granulomatous disease of unknown etiology, affecting multiple organ systems
- Most common in black women
- Approximately 25% of patients have cutaneous involvement, most commonly presenting as violaceous nodules, particularly on the face.
- Normally, non-necrotizing granulomas are distributed throughout the dermis.
- The granulomas are often surrounded by a lymphocytic infiltrate.
- If the subcutis is involved, caseation may sometimes be seen.
- Asteroid bodies, Shaumann bodies and Hamazaki-Wasserman bodies may be seen, but are nonspecific.